DXM + Bupropion

I'm mining this post for reports. This one is pretty short and straightforward. I had just been prescribed a higher dose of my medication, Bupropion. I was now taking 450 mg a day, and the effects on my sober life were pretty apparent with light visuals and a general feeling of spaciness and hypomania. This would be the first night I would realize its enzyme-inhibiting properties and how that affects the DXM experience. At the time however, I had no idea what was going on. I also met my girlfriend for the first time during the course of this report... If yr reading, I love you v much <333

Sorry it's so short and sorry there are no timestamps. My recollection of the experience was very foggy and episodal. 

The report has been edited slightly from its original version.

Age: 19

Weight: 135 lbs

Dose: 200 mg DXM, 450 mg Bupropion

Setting: My friend's house

Take 200 mg of DXM at a party, it is mixed into a bottle of ginger ale. The drink is bitter and gives me chills. It is pretty nasty, but definitely bearable and about as drinkable as hard alcohol. For about an hour I am coming up, I am feeling definite dissociation and a general spaciness. Around the comeup, my memory begins to blank and fall away. Everything feels very distant, it is like everything that is more than 5 feet away has just been swirled and blurred into abyssal nonsense. I think I am visibly intoxicated, moreso than anyone else there. One of the people who lives at the house offers me to chill out in her room, probably because I was talking about the visions I got from closing my eyes. Also my eyes had turned deep deep blood red, more than anyone gets from being stoned, it probably looked very off. These visions included:

A procession of strange geometric alien figures, marching on a bridge between two mountains. They are strange solid pastel colors. Some have eyes or discernable features, but they all have strong right angles and straight lines, as if they have been molded or produced. I am merely a witness to these visions, I do not interact with them. I am a stationary camera watching them from afar.

A huge detailed ship crawls across my vision. It feels like a spaceship, because its just kinda floating in empty abyss, but there is definitely an open deck on top, which would make no sense in space. There are canopied spaces and all variety of boxes and clutter on the deck. It is very washed out and dark and gloomy seeming, the entire vision is washed out. 

I end up in the basement of the house somehow. I don't remember much of what I was doing down here until people came down to visit me. I felt like I had been trying to fall into a trance, to tap back into that deeper world, but I was coming down. I lamented that the universe of dextromethorphan had now closed its gates to me. One vision towards the end that I recall was a landscape with dead trees. I don’t remember too much of this one, other than a blue glow on the horizon.

The next morning I feel very spacey and dissociated. This feeling lasts all day, it is like I was just high and slightly dissociated when I woke up. This doesn’t wear off until I have been awake for about 12 hours.

DXM

I'm mining reports from this post, just because I felt like they were different enough to be worth separating into separate posts. There is certainly some novel value present in some of the combinations. This report is just plain old DXM however.

Age: 19
Weight: 135 lbs
Dose-600 mg oral
Setting-My apartment

T0:00-Begin drinking cough syrup. Try mixing it /chasing it with ginger ale. Its easiest to drink if I just chase it. Manage to slug down one bottle in about 5 minutes.

T0:25-Manage to drink the second bottle by now. Already feeling slightly dissociated. Nausea is coming on strong, this stuff is absolutely disgusting.

T0:40-I am being drowned in a big swirling ocean of syrup. The swells toss me about and mold my form like I am made of soft clay. I do not feel a progression through plateaus, rather I am just sinking deeper and deeper into the dex sea. It reaches a point where I can no longer see straight with both eyes open, I get the classic dissociative double vision. (I am on MXE while I write this oops). It follows with this sense of just being completely and totally lost in my own room, I do not know where I am, when I am, why I am, how I am, I am wiped clean and left confused. It feels like my stomach is boiling. I know I have to hold it down as long as possible to absorb as much as I can. I know vomiting is near inevitable.

T0:45-The yak comes. I throw up red syrup in a hideous cascade. Wow this feels terrible wow. I never liked vomiting, it is painful, it is uncomfortable, it makes my eyes water it makes it feel like my body is dismantling. But I get it out, I feel a bit disappointed that I wasn’t able to keep it down for longer, I will not get the full experience I desired I’m pretty sure.

T???-Per usual the next however many hours is a dissociative black out fog, timeless and punctuated by brief moments of relative clarity. What I can remember is open eyed visuals taking the form of warping and bulging of the space around me, it looked like the world had turned to syrup and was tilting in every direction slowly. I lost all sense of space, if I closed my eyes and opened them again I would feel completely lost, with no idea of what was up, down, left, right, forward, backwards, I felt like I was the objects around me, not an independent being. Walking was pretty much impossible.

If I closed my eyes, it would be an instant OBE. No calm and gradual fading of myself, I was immediately cast into the dizzying void. Each time my eyes closed, a similar journey would take place, with the same sequence. First I would see the room around me. It looked normal, with the colors being heavily saturated. Soon though, the dream space would collapse into the swirling abyss, come apart piece by piece and dissolve into nothing. I would be in a vast place I would call the dream nexus. It seemed like an impossible huge spherical void, which I was free to float in. The walls of this shell were covered with a grid of hundreds of thousands apertures. This is where things got a bit confusing/

If I were to float in an aperture, I would awake, in my bed again. I would get up and explore my house, and encounter people I knew, either people I lived with, friends, or sometimes strangers. We would interact, everything seemed very off though. We spoke in terse non-sequiturs. I don’t remember any of what was said but it was all surreal and emotionally empty. Everyone was emotionally empty and the color was drained of the world. This whole time I was actually still just lying in bed with my eyes closed. I could reset the cycle by opening and closing my eyes.

With eyes open, a similar effect took hold, as if my brain was trying its hardest to imbue this feeling in me no matter my state. Objects around me would morph into people, familiar people. They would just stand there, merely exist, looking like furniture. They kept appearing around me, hanging around me, I didn’t feel alone in my room at all, and In retrospect I ended up having to ask my roommates if I really interacted with any of them during that timespan (I didn’t).

T5:00-I wake up. I don’t know if I fell asleep or if the past 3 hours have been a total blackout. I am down enough to have functional motor skills, and it seems like my memory has touched down and is recording again. I still feel VERY dissociated and spacey, I still have the “dex walk” and still feel like everything is in motion. I have a sense of direction again, and the visual effects have died down other than vision being super blurry. I hang out with my roommates and go scavenging for junk with them the rest of the night.

T9:00-I go to bed, still feeling spacey. I wake up the next morning still feeling like I am on a low dose of dex. Still feel the dex walk, but its not apparent and I look normal enough. The world feels dreamlike and unreal, it seems like everything is just fading into the background of existence. I have an appointment with my therapist and he’s a bit irked that I’m altered while there. I still have vivid CEV’s, and if I close my eyes long enough I can really sink into them and almost sort of lucid dream. They are no longer replicated from the world around me, but rather are randomly generated. They take the form of tunnels and moving geometric objects.

DXM + DPH + Bupropion + Gabapentin

This was originally part of this post, but I decided it was enough of a unique combination to warrant its own post. This was an experience from almost 2 years ago. This was a combination that I indulged in quite a bit for the months after, the effects were absolutely unlike any other drug I had tried, it was a combination that was totally novel and unique. This is likely due to the Sigma-1 receptor agonist activity of unmetabolized DXM. I would love to explore other drugs with similar receptor affinity. This report is short and sweet as there was quite a bit of amnesia, no timestamps even, sorry. It's been edited from its original version to include the aftereffects, Nonetheless,

Age: 19
Weight: 135 lbs

Dosage: 120 mg DXM, 600 mg Bupropion, 150 mg DPH, 3 g Gabapentin

Setting: My apartment

I had a little bit of DXM left, and didn’t feel like going all the way to the store for more. I wondered how I could make it go a long way. I had been reading earlier about the action of CYPD2D6 inhibitors and the effects they can have on DXM. I happened to be prescribed one of the most potent ones. I was already taking 450 mg a day. I figured throwing another 150 mg on would make for an interesting interaction. I decided to add some DPH to the mix too, both for its deliriant properties and because it too is an inhibitor. Because bupropion lowers a person’s seizure threshold I decided to take a ton of gabapentin too (I am prescribed 300 mg 3x a day).

I don’t remember the comeup much, but I was cast into the familiar state of everything seeming distant and metallic. Everything seemed to have rippling outlines, with tiny thin hairs sticking out of these auras. It was like everything had a hairy aura I guess. I began to feel like I had company, it was that feeling of the objects around me being people, seeing something from the corner of my eye triggered a strong feeling of sharing the space with another presence. I was alone for this entire experience.

I went outside to sit in my backyard and smoke, It was a nice dusk and the sunset was serene and pleasant. While lying back there, I got a very vivid hallucination-A black cloud, looking like a really thick puff of smoke, crawled across the sky like an amoeba with pseudopods. It appeared to be 15 feet off the ground or so. It reached powerlines, at which point it bent and altered its “limbs” to crawl over them. It the flashed out of existence. This was wild, the powerlines looked hairy and everything still had that aura. These hallucinations were unlike anything from psychedelics, they were not patterns or alterations, but just total hallucinations. I spent the next hour and a half relaxing back there, and the entire experience is a strange hallcucinatory circus. The entire time, it feels like I am hanging out with my friends back there like I have been pretty often at night the past few weeks, they are communicating and interacting with me and each other. They are hanging around, smoking, passing around a piece and joking and being warm presences. Of course in reality, I am completely alone. These people barely even manifest visually- They only appear in the corners of my eyes, and when focused on they vanish. They are faceless, featureless, grey and ethereal. They are loosely based off of real people I know, they are sentient silhouettes, ghosts if you will. Sometimes they are standing, looming, walking around, and we both feel like we notice one another. But once again, no one there, absolutely nobody.

The next day, I am still pretty dissociated when I wake up. I feel kinda numb and just very altered. Dex walk is still apparent. Upon smoking, I am blasted right back into the dexosphere. I no longer have the hallucinations of other presences. Rather, I am stricken with debilitating dissociation and super clear and vivid closed eye visuals. This time, I am floating above detailed landscapes, with rivers, rolling hills, and completely desolate terrain, devoid even of plant life. Other hallucinations include the typical zooming through a tunnel or between pillars.
The next day I wake up in the early afternoon still feeling pretty dissociated, like the syrup has stuck to my insides and now refuses to be extricated. I go through the day in a dizzy haze, still robowalking and still feeling uncoordinated and numb. When i smoke weed, it feels like I am in the depths of the DXM experience again. My sense of proprioception collapses inwards as my body begins to go numb. I am couchlocked and stricken with the most vivid closed eyed visuals of maps, landscapes, trees and buildings, all tinted grey and maroon and swirling with an alien sickness. I feel a restless itchiness in my joints and extremities. I keep smoking and it keeps me feeling dissociated throughout the day. This feeling only begins to fade around nightfall. 

3-MeO-PCE + 3-MeO-PCP

Age: 21

Weight: 120 lbs

Dosage: 25 mg 3-MeO-PCE + 10 mg 3-MeO-PCP both Intranasal

Setting: My apartment

T0:00- Both drugs mixed and cut into a single line. Snorted all at once, it stings quite a bit.

T0:05- Feeling a bit dizzy and lightheaded already.

T0:10- I am shaking quite a bit, this is unlike any other dissociative comeup I’ve experienced so far. It’s as though I have just kicked off a chain reaction bearing an immense amount of potential energy that is slowly leaking into me, foreshadowing the full force and fury of what is to come. I am fading more and more as it feels like my body is being sucked away from me by a giant vacuum. My fingers begin to move more slowly as I become more fuzzy and numb. Memories flit around my head as rectangular butterflies.

T0:20- The potential energy is burgeoning and bubbling with an unexpected fury. I begin reflecting on my memories, the memories of that day, the memories of the past week, they always present as strange alienated vignettes, seemingly divorced from my actual self. It’s like they are all being viewed through some icy screen that saps the memories of any emotions mental entanglements. My fingers feel numb and mechanical.

T0:30- At last, the great rising bubble begins to crackle at the seams. Raw energy is expulsed with immense pressure, screaming down my limbs, spraying spitfire into my bones and electrifying my extremities. My back arches and my muscles twitch with this sudden influx of unfettered power. My thoughts are racing faster than I can manage, but it’s not distressing, rather I am distracted by the bustling fury with which I try to keep up with them.

Soon it feels as though I am simply moving faster than the world around me. Everything surrounding me seems to lapse into slow motion, even the music I am listening to. It’s like the soundwaves have slackenedto a more manageable speed and I can now meticulously weasel in and dissect every little fragment of the sounds with my ears. This must be how a hummingbird feels. I begin getting open eyed visuals of blocks and rod-like forms forming into great palisades around me, towering walls of pillars jutting from the ground. It is as if time has slowed down to the point where it is freezing and crystallizing into these solid forms.

T0:45- I apparently spend this span of time dressing up in my various costumes and dancing around my room, playing with my various dead animal parts. I know this because I recorded the whole thing on my webcam, though I have very faint recollection of this. I am not sure what drove me to do this, perhaps some desire to perform some “ritual” or to try and contact some metaphysical aspect of the experience. Nevertheless, the footage is nothing short of inane absurd madness. I felt like I had some grand purpose in mind while doing this, that I was maybe creating some art piece or really truly reeling in some arcane forces. Setting it up was a substantial effort, and this combination of drugs does not seem to hesitate in stoking the fires beneath me and electrifying me with motivation. I feel like with the proper directive, I could do anything right now. My motivation is astronomical, for no reason other than to expend the pure energy bursting from my every nerve. I feel incredibly warm and fuzzy, and my movements are carefree and uncoordinated. It’s a miracle that I somehow didn’t hurt myself in all of this activity.

T1:15- I thought I had peaked when I had been driven into that dance of madness. Nope, it seems this combination takes quite a bit of time to really get going. All of my notes from here on out were written in all caps. I suppose I felt that lowercase letters could not properly contain my energy. I feel ‘spun out’, in the purest and strongest regard. It feels like my physical body is in constant motion, that it is a gelatinous form being whipped and frothed by raging winds or tossed about by raging centrifugal, and that I am struggling to keep my mind in place within this wavering frame. I feel as though a solid form is no longer sufficient to contain this energy, that every atom in my body had been excited to the point of detaching from one another and liquefying. It feels as though some unknown force is punching and pulsing and rippling my liquid form, not out of malice but simply as collateral damage from its quivering, pummeling energy. This is not so much a heavy debilitating bodily dissociation, rather it is an all-consuming thrashing maelstrom of mental dissociation. I do not think I have ever felt so violently torn away from myself.

My notes for this portion of the experience border on incoherency. What little I could glean in a sober state was mostly in regards to bodily sensations- Feeling as though my body is being shorn apart by gale force winds, feeling as though I have been painlessly dismembered and split into separate parts, feeling as though I am being pelted with a hail of blocks, feeling like my body is shattering into tessellated fragments, feeling like I am imploding into myself, feeling stuck and held forcefully into place as the world rushes around me. The incoherent jumble of descriptions is fraught with dark and sinister imagery, a lot of it deals with having my body being forcefully taken to pieces or destroyed in some way. I am really, truly lost in my own room.

T1:35- I do not feel human, I do not even know what human means. My world is this strange self-contained sphere, a partitioned vesicle separate from the consequences of whatever lies beyond my bubble. The space within this bubble plays by its own rules, follows its own physics, has its own sense of time and space. It still feels as though I am being sheared apart by hurricane force winds.

I close my eyes and it feels like part of me is rising into the sky, while another part of me is being sucked forcefully downward into oblivion. I am being pummeled still by little vibrating fists and my memories are being scattered about like someone throwing a deck of cards up into the wind. I am adrift in a storm of walls.

T2:00- The experience shows no signs of letting up. Great dissociative gods loom over me and watch me as I continue to be tumbled around inside the infinite anesthetic maelstrom. I am still being stretched between things, split into pieces, all of this is absolutely relentless. It’s like they have tossed me into a dryer and turned it on full force, for nothing other than their absurd, maddened entertainment.

T3:00- I’ve been playing a little videogame to try and pass the time faster, as it still feels as though time is moving slower than normal. Even after all this time passes, I don’t feel like I’m coming down at all, the storm rages with a fury that has only diminished ever so slightly. Everything is flashing and pulsing still, and I am still altered beyond any sense of functionality. The boundaries of my body are still amorphous and gelatinous, it still feels like a dissociative gale is raging around me, mentally, I still feel starkly and acutely separated from the world.

T4:00- Only now can I start to say that I am beginning to come down, but just barely. I go downstairs and hang out with my roommate. Interacting with people is very challenging as I just feel alien and inhuman, and my mind feels scarred and abraded from the sheer force of this combo.

T5:00- Go out in public to a convenience store. It’s extremely odd, I have very little sense of body and feel like I am just a head and shoulders zooming around, with no sense of how tall I am or how much space I occupy. Visually, things are still flashing, pulsing, beating and throbbing.

T6:00- I go to bed now, still feeling very dissociated. I don’t have any problem sleeping though, despite how heavily and irredeemably stimulated I felt earlier.

Aftermath: The next day I sleep in. I don’t feel too dissociated when I wake up, just the usual afterglow. Throughout the whole experience, the sheer force of the dissociation was so severe that I couldn’t comprehend ever recovering from it, yet here I felt the next day mostly normal and recovered. It’s nice how that turns out.

This is a very intense combination, it seems to really drag out the duration of both drugs and bombard the user with an unrelenting and extremely intense dissociative storm, similar to the merciless and uncompromising nature of O-PCE. Approach with caution.