PThP

 Age: 26

Weight: 130 lbs

Dosage: 250 mg oral in gel cap

Setting: My house

 

Preface: I was privileged to be one of the first people in human history to ingest the drug PThP, for which there is no prior documentation. The only relevant information I could gather was a thread on Bluelight, where a user claimed to have read an article in the European Journal of Medicinal Chemistry that stated that this compound demonstrated NMDA receptor affinity and antagonist action from PThP. Unfortunately they (and no other users) were actually able to locate this article.

Chemically speaking, PThP would be considered an Arylthianylamine, as opposed to an Arylcyclohexylamine. As the name states, it has the structure of an arylcylohexylamine, but with the cyclohexane ring replaced by a 4-thiane ring, a saturated (single bonds only) 6-member carbon ring where one of the carbons is replaced with a sulfur, in this case the carbon opposite of the amine/phenyl ring. PThP is the Arylthianylamine analogue of PCP. Per naming conventions, other amines would bear other suffixes, like PThE as an analogue of PCE.

Several studies have demonstrated that messing with the middle cyclohexane ring tends to stifle NMDA-antagonist activity in aryl-x-amines. Making it into a 5-member cyclopentane or a 7-member cycloheptane sees a steep drop in activity. The sulfur however, seems to conserve activity, perhaps by roughly maintaining the size of the middle ring so it still fits snugly in the channel of the NMDA receptor, blocking it and producing familiar dissociative effects. As is seen in a number of other psychoactive compounds, an oxygen can be exchanged for the sulfur and conserve activity, forming an oxane ring, referred to as an aryloxanylamine (This is a claim that is unpublished elsewhere that I discovered on my own- the resulting compound, POxP, which pends a future report, is active though less potent than PThP).

I first attempted to titrate up doses with POxP, which demonstrated a very low potency, with threshold effects only being observed well over 100 mg orally. I felt confident starting with a fairly high dose of PThP, finding threshold effects at 100 mg. The report that follows is for a single 250 mg dose taken orally in a gel cap. The overall duration of the experience was about 5 hours, I found it to be a fairly unremarkable and light dissociative, but I think it is still a fascinating compound, especially in its further implications in the activity of aryl-x-amines. I personally find it very exciting that there is a whole world of potential compounds contained in altering the supposedly untouchable middle cyclohexane ring! Perhaps other modifications to the molecule like substitutions on the phenyl ring could yield more interesting effects to explore or boost the potency. In my opinion it is something very well worth investigating into the future.

 

T0:00- Dose taken.

 

T0:40- I have been facetiming with a close friend who is dyeing her hair. We chat and as we interact I begin to notice the first notes, a sense of feeling a bit floaty and heavy. I am certain that this is not any sort of placebo effect.

 

T1:07- The call ends. I take stock of what sets in, a dissociation that could only be described as heavy and stretchy.

 

T1:12- The most distinct way the dissociation manifests now is a sense of constant motion, as though my brain were an intangible entity separate from my skull, its phantom-form taken up in the rushes of a running stream, dissolving into the currents and being dragged into the unknown distance. The waters are exactly the temperature of my body. It is like a sterile wind, neutral and always moving. I feel heavy. There is a swirly heavy drunkenness like my head has turned to a dense mass of viscous black lava, slowly seeping and drooping and pulling me to the earth at the mercy of gravity, its black skin cracking and separating to exude the glow of the energy that lies beneath. There is a tightness in my body as my skin begins to go numb like I am being bound by something invisible. My breathing is conscious and labored, the entire world feels heavy around me. The walls may sink further into the earth at any moment.

 

T1:20- My visual field stretches away from me, creating some strange imperceptible space between my mind and my senses. Everything has a sensation of being distant, despite no clear discernible change in my visual input. The sensory information resonates and distorts in this empty space, where it is free to flow and mingle and tangle and present itself to me at the drug’s behest. Light visuals begin to present, for the most part in a subtle strobing of my visual space. Faint colors flash in occasionally, timid golden hues and pale, understated reds. There are subtle quadrilateral patterns on the walls, though they are hard to discern.

There is not much stimulation, not much of a sense of rushing or being forcefully drawn into the experience. There is a steady motion, slow and deliberate, as purposeful and inevitable as a bathtub filling with water. I stand up and move, my limbs feel heavy and numb, but I am otherwise fairly functional, able to walk steadily, carry objects and interact with my environment. The experience bakes into me a bit but I for the most part feel lucid. My partner is upstairs giving a mutual friend a haircut, I am downstairs alone in the dark. I go up and am easily able to maintain brief conversation with them both. This is ultimately a fairly mild experience. There is however, a perpetual sense of sinking further and further into the Earth.

 

T1:30- I am a heavy piece of steel, cold and still and inhuman. My fingers are light and uncoordinated, typical of dissociatives. Their movements are more a function of muscle memory than anything within what my mind and body can coordinate. The numbness on my skin gives way to a sudden sensitivity. I want to lie and stretch out and rub myself on the soft surfaces around me like a cat squirming in a sunbeam. Everything feels so baseless and unstable, I am treading water or flitting about in the wind, totally unanchored. None of this particularly stands out from other dissociatives I have experienced, such as ketamine. It is a pretty standard suite of effects, for now mostly characterized by a dazed empty-headedness, a sensation of steady flowing and a sterile dryness to my skin and being, and most of all an odd contradiction of at once feeling very heavy and dense yet at the same time feeling light, flighty, floaty, and unbound.

 

T2:00- This has been a steady peak. I am disoriented and distractible. I smoke a bit of cannabis and this mostly just serves to stimulate my flow of thoughts. I am still alone downstairs, wondering how to occupy my time. I close my eyes and put in headphones and listen to some music to try and immerse myself fully in the effects. I am cast into a world of some vocaloid shoegaze artist (re;mo, album “Nanairo”), untethered from my body and sunken into a synesthetic landscape of subtle dimmed hues and feeble geometric forms. With a more intense experience, closing my eyes and listening to music through headphones is a surefire way to shed my physical form and project into a hallucinatory consciousness; my sense of body gains a phantom mobility, develops odd proportions and bends and twists and contorts in impossible ways, there is a sense of losing gravity, of flying or levitating, of a great soft pressure pushing in from all sides. With this I am still quite aware of m­­y body, of the surface it rests on and the memory of the space around me. I know exactly where I am, what my body is doing, I am mostly dizzy and dazed and drawn into the sensory experience like I am peeking under the surface of the ocean with a mask and snorkel, as opposed to diving all the way into its infinite depths.  My notes turn to gibberish at this point, probably from trying to type with my eyes closed, relying on a distorted muscle memory in my fingers. The waves wash over me. I am oily, swirling around my surroundings but not dissolving into them. With my eyes open those same quadrilateral visuals become tracery and latticework on the walls.

 

T2:30- already feels like a descent. I am lucid enough to read and browse the internet and take in information, this so far has not been intense enough to induce the dissociative double-vision that often renders me illiterate. I spend my time on 4chan of all places just out of sheer curiosity for what it has become in this day and age. I used to be a habitual browser of 4chan when I was a teenager, for better or worse (probably worse) it was a formative place that affected much of my development and socialization. It was where I first learned about research chemicals in fact. I aimlessly scroll through /b/ like I used to, it was once a place of familiarity and comfort, where I could talk about whatever with no consequence. It is the same as always really, just a lot of porn, people playing games with the post numbering system, people just dumping image collections and some discussions overflowing with toxicity and bad advice. It felt bigger, more important, and most of all, more entertaining back then. This does nothing for me anymore. I guess one can never go back. I decide to indulge in other nostalgia and play some flash games. These activities and interactions feel meditative but ultimately just like aimless stimulation, matching the experience- aimless, directionless, just empty interaction and the induction of an empty dissociative state.

T2:46- Going down, still a bit dizzy, still feels like I’m trailing off of the peak. There is not much to note or describe anymore beyond the steady descent to baseline in a relatively short span of time.

 

T3:18- The experience is mostly gone. I am still just hanging out by myself in the dark browsing the vast internet.

 

T4:30- Back to baseline.

 

Conclusion:

There’s no denying that PThP represents a really interesting development in the field of aryl-x-amines. The fact that the supposedly untouchable center ring can in fact be altered and still yield an active dissociative is really fascinating to me! What’s lacking is any magic or appeal in the actual experience- yes it is active, but it is not particularly interesting or engaging. It checks the bare minimum for being an active dissociative- it induces all of the familiar effects- Numbness, a loss of proprioception, a sensation of motion or sinking, a perceived sense of visual distance and derealization, dizziness and lightheadedness, a bit of stimulation, some light visuals. It lacks much depth beyond that however, it is a hollow and basic experience that really defies further description, not because it was so severe and baffling but because it felt so limited. There was little in the way of emotional depth, there was perhaps a bit of introspection and insight but it was buried in a hollow and dry and empty space, bathed in sterile light and dark. The experience was short, it was fairly light and nondescript, and most unfortunately of all, a very large quantity of the compound had to be consumed to induce this much of an experience. It was boring, but the implications are far more interesting- are there modifications to this base scaffold that would yield more interesting effects? Higher potency, longer duration, deeper insight? Perhaps there are, perhaps there aren’t, and only dedicated exploration (without promise of meaningful results!) will reveal that. For now I am happy to contribute this one data point to the pool of nonexistent information on this compound or any related compounds.